Strain Name | C57BL/6-Masp2tm1(MASP2)Bcgen/Bcgen | Common Name | B-hMASP2 mice |
Background | C57BL/6 | Catalog number | 110872 |
Related Genes |
sMAP; MAP19; MASP-2; MASP1P1 |
Protein expression analysis
Analysis of blood T cell subpopulations by FACS. blood cells were isolated from female C57BL/6 and B-hMASP2 mice (n=3, 6-week-old). Flow cytometry analysis of the blood was performed to assess leukocyte subpopulations. A. Representative FACS plots. Single live CD45+ cells were gated for TCRβ+ T cell population and used for further analysis as indicated here. B. Results of FACS analysis. The percent of CD8+ T cells , CD4+ T cells and Tregs in homozygous B-hMASP2 mice were similar to those in the C57BL/6 mice, demonstrating that MASP2 humanized does not change the overall development, differentiation or distribution of these cell types in blood.